Assay Detail
Binding
CHEMBL660365
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Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2720) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Analogs of CCK incorporating conformationally constrained replacements for Asp32.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.23 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438911 | — | — | 1 | 7.66 |
| CHEMBL263155 | — | — | 1 | 6.77 |
| CHEMBL411202 | — | — | 1 | 6.70 |
| CHEMBL411079 | — | — | 1 | 5.64 |
| CHEMBL407530 | — | — | 1 | 5.41 |
| CHEMBL385727 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438911 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL263155 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL411202 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL411079 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL407530 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL385727 | — | IC50 | = | 6160.0 | nM | 5.21 |