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Assay Detail

CHEMBL660380

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibitory effect on human recombinant liver cytochrome P450 2C18 expressed in yeast strain
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cytochrome P450 2C18 (CHEMBL2408)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.
Ha-Duong NT, Dijols S, Marques-Soares C, Minoletti C, Dansette PM, Mansuy D.
J Med Chem (2001) 44 : 3622 -3631
PubMed 11606127 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.95 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL121503 1 5.52
CHEMBL121323 1 5.52
CHEMBL121420 1 5.40
CHEMBL120426 1 5.30
CHEMBL331485 1 5.22
CHEMBL330871 1 5.16
CHEMBL120797 1 5.16
CHEMBL120183 1 5.10
CHEMBL121522 1 5.10
CHEMBL121048 1 5.05
CHEMBL414238 1 5.05
CHEMBL333704 1 5.00
CHEMBL332958 1 4.92
CHEMBL443542 1 4.82
CHEMBL333210 1 4.75
CHEMBL121040 1 4.70
CHEMBL333108 1 4.70
CHEMBL121241 1 4.52
CHEMBL120825 1 4.52
CHEMBL1109 SULFAPHENAZOLE 4.0 1 4.22
CHEMBL331431 1 4.19
CHEMBL332994 1 -
CHEMBL432386 1 -
CHEMBL332690 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL121503 IC50 = 3000.0 nM 5.52
CHEMBL121323 IC50 = 3000.0 nM 5.52
CHEMBL121420 IC50 = 4000.0 nM 5.40
CHEMBL120426 IC50 = 5000.0 nM 5.30
CHEMBL331485 IC50 = 6000.0 nM 5.22
CHEMBL330871 IC50 = 7000.0 nM 5.16
CHEMBL120797 IC50 = 7000.0 nM 5.16
CHEMBL120183 IC50 = 8000.0 nM 5.10
CHEMBL121522 IC50 = 8000.0 nM 5.10
CHEMBL121048 IC50 = 9000.0 nM 5.05
CHEMBL414238 IC50 = 9000.0 nM 5.05
CHEMBL333704 IC50 = 10000.0 nM 5.00
CHEMBL332958 IC50 = 12000.0 nM 4.92
CHEMBL443542 IC50 = 15000.0 nM 4.82
CHEMBL333210 IC50 = 18000.0 nM 4.75
CHEMBL121040 IC50 = 20000.0 nM 4.70
CHEMBL333108 IC50 = 20000.0 nM 4.70
CHEMBL121241 IC50 = 30000.0 nM 4.52
CHEMBL120825 IC50 = 30000.0 nM 4.52
CHEMBL1109 SULFAPHENAZOLE IC50 = 60000.0 nM 4.22
CHEMBL331431 IC50 = 65000.0 nM 4.19
CHEMBL332994 IC50 = 150000.0 nM -
CHEMBL432386 IC50 = 170000.0 nM -
CHEMBL332690 IC50 = 125000.0 nM -