Assay Detail
Functional
CHEMBL660424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of colon 26 adenocarcinoma cells by 50 %.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Colon 26 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.18 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 8.29 |
| CHEMBL103582 | — | — | 1 | 8.23 |
| CHEMBL102838 | — | — | 1 | 8.09 |
| CHEMBL105075 | — | — | 1 | 7.90 |
| CHEMBL103856 | — | — | 1 | 7.75 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.75 |
| CHEMBL102949 | — | — | 1 | 7.74 |
| CHEMBL103329 | — | — | 1 | 7.65 |
| CHEMBL103062 | — | — | 1 | 7.63 |
| CHEMBL103288 | — | — | 1 | 7.44 |
| CHEMBL103333 | — | — | 1 | 7.36 |
| CHEMBL102711 | — | — | 1 | 7.24 |
| CHEMBL102944 | — | — | 1 | 7.21 |
| CHEMBL322446 | — | — | 1 | 7.20 |
| CHEMBL422246 | — | — | 1 | 7.16 |
| CHEMBL441739 | — | — | 1 | 6.87 |
| CHEMBL319183 | — | — | 1 | 6.71 |
| CHEMBL102557 | — | — | 1 | 6.67 |
| CHEMBL101377 | — | — | 1 | 6.65 |
| CHEMBL317013 | — | — | 1 | 6.63 |
| CHEMBL102702 | — | — | 1 | 6.44 |
| CHEMBL320679 | — | — | 1 | 6.14 |
| CHEMBL316750 | — | — | 1 | 5.84 |
| CHEMBL103653 | — | — | 1 | 5.62 |
| CHEMBL102235 | — | — | 1 | - |
| CHEMBL105217 | — | — | 1 | - |
| CHEMBL103174 | — | — | 1 | - |
| CHEMBL322173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL103582 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL102838 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL105075 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL103856 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL102949 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL103329 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL103062 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL103288 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL103333 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL102711 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL102944 | — | IC50 | = | 61.7 | nM | 7.21 |
| CHEMBL322446 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL422246 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL441739 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL319183 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL102557 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL101377 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL317013 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL102702 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL320679 | — | IC50 | = | 722.0 | nM | 6.14 |
| CHEMBL316750 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL103653 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL102235 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL105217 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL103174 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL322173 | — | IC50 | > | 3000.0 | nM | - |