Assay Detail
Binding
CHEMBL660485
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Inhibition of human coagulation factor II
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.92 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431666 | — | — | 1 | 6.70 |
| CHEMBL93854 | — | — | 1 | 6.69 |
| CHEMBL332121 | — | — | 1 | 6.58 |
| CHEMBL332256 | — | — | 1 | 6.56 |
| CHEMBL333678 | — | — | 1 | 5.98 |
| CHEMBL327600 | — | — | 1 | 5.84 |
| CHEMBL119881 | — | — | 1 | 5.71 |
| CHEMBL120629 | — | — | 1 | 5.65 |
| CHEMBL119966 | — | — | 1 | 5.65 |
| CHEMBL332650 | — | — | 1 | 5.58 |
| CHEMBL420546 | — | — | 1 | 5.55 |
| CHEMBL120413 | — | — | 1 | 5.52 |
| CHEMBL324793 | — | — | 1 | 5.40 |
| CHEMBL121575 | — | — | 1 | 5.40 |
| CHEMBL120384 | — | — | 1 | - |
| CHEMBL333548 | — | — | 1 | - |
| CHEMBL326704 | — | — | 1 | - |
| CHEMBL331561 | — | — | 1 | - |
| CHEMBL118304 | — | — | 1 | - |
| CHEMBL433644 | — | — | 1 | - |
| CHEMBL331666 | — | — | 1 | - |
| CHEMBL118392 | — | — | 1 | - |
| CHEMBL119773 | — | — | 1 | - |
| CHEMBL434219 | — | — | 1 | - |
| CHEMBL326959 | — | — | 1 | - |
| CHEMBL330960 | — | — | 1 | - |
| CHEMBL118989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431666 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL93854 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL332121 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL332256 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL333678 | — | Ki | = | 1051.0 | nM | 5.98 |
| CHEMBL327600 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL119881 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL120629 | — | Ki | = | 2228.0 | nM | 5.65 |
| CHEMBL119966 | — | Ki | = | 2219.0 | nM | 5.65 |
| CHEMBL332650 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL420546 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL120413 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL324793 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL121575 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL120384 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL333548 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL326704 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL331561 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL118304 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL433644 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL331666 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL118392 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL119773 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL434219 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL326959 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL330960 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL118989 | — | Ki | > | 4000.0 | nM | - |