Assay Detail
Binding
CHEMBL660486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro evaluation of inhibitory activity against Coagulation factor II in prothrombinase complex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.86 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315218 | — | — | 1 | 5.87 |
| CHEMBL327600 | — | — | 1 | 5.85 |
| CHEMBL86343 | — | — | 1 | - |
| CHEMBL83532 | — | — | 1 | - |
| CHEMBL1907672 | — | — | 1 | - |
| CHEMBL419490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315218 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL327600 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL86343 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL83532 | — | Ki | ~ | 4000.0 | nM | - |
| CHEMBL1907672 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL419490 | — | Ki | ~ | 4000.0 | nM | - |