Assay Detail
Binding
CHEMBL660487
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Inhibition of Coagulation factor II
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.72 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290376 | — | — | 1 | 10.38 |
| CHEMBL175398 | — | — | 1 | 8.15 |
| CHEMBL422722 | — | — | 1 | 8.13 |
| CHEMBL174456 | — | — | 1 | 7.75 |
| CHEMBL366643 | — | — | 1 | 7.72 |
| CHEMBL367626 | — | — | 1 | 7.62 |
| CHEMBL170063 | — | — | 1 | 7.62 |
| CHEMBL174008 | — | — | 1 | 7.55 |
| CHEMBL173612 | — | — | 1 | 6.85 |
| CHEMBL171390 | — | — | 1 | 6.68 |
| CHEMBL368131 | — | — | 1 | 6.52 |
| CHEMBL173765 | — | — | 1 | - |
| CHEMBL177038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290376 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL175398 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL422722 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL174456 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL366643 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL367626 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL170063 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL174008 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL173612 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL171390 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL368131 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL173765 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL177038 | — | Ki | > | 21000.0 | nM | - |