Assay Detail
Functional
CHEMBL660575
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Effective concentration evaluated in light induced toxicity toward COLO-26, murine colon carcinoma cell line after irradiation with 15 J/cm**2 of 360-800nm light
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Colon 26 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.32 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356183 | — | — | 1 | 7.16 |
| CHEMBL339865 | — | — | 1 | 6.70 |
| CHEMBL141536 | — | — | 1 | 6.70 |
| CHEMBL129077 | — | — | 1 | 6.52 |
| CHEMBL356702 | — | — | 1 | 6.43 |
| CHEMBL147009 | — | — | 1 | 6.22 |
| CHEMBL149501 | — | — | 1 | 6.10 |
| CHEMBL146277 | — | — | 1 | 5.92 |
| CHEMBL150126 | — | — | 1 | 5.72 |
| CHEMBL148507 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356183 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL339865 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL141536 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL129077 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL356702 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL147009 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL149501 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL146277 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL150126 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL148507 | — | EC50 | = | 2000.0 | nM | 5.70 |