Assay Detail
Binding
CHEMBL660641
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Inhibitory concentration against recombinant human cathepsin L was determined in a fluorescence assay using 5 uM Cbz-Phe-Arg-AMC as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.31 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114462 | — | — | 1 | 7.82 |
| CHEMBL116779 | — | — | 1 | 6.96 |
| CHEMBL116402 | — | — | 1 | 6.57 |
| CHEMBL114161 | — | — | 1 | 6.13 |
| CHEMBL116724 | — | — | 1 | 5.92 |
| CHEMBL117658 | — | — | 1 | 5.70 |
| CHEMBL117144 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114462 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL116779 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL116402 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL114161 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL116724 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL117658 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL117144 | — | IC50 | = | 8500.0 | nM | 5.07 |