Assay Detail
Binding
CHEMBL660643
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Inhibition of human cathepsin L.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.21 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341197 | — | — | 1 | 9.13 |
| CHEMBL134494 | — | — | 1 | 9.02 |
| CHEMBL336591 | — | — | 1 | 9.02 |
| CHEMBL136252 | — | — | 1 | 9.01 |
| CHEMBL336415 | — | — | 1 | 8.85 |
| CHEMBL1790993 | — | — | 1 | 8.72 |
| CHEMBL1790991 | — | — | 1 | 8.70 |
| CHEMBL1790989 | — | — | 1 | 8.70 |
| CHEMBL1790996 | — | — | 1 | 8.68 |
| CHEMBL1790999 | — | — | 1 | 8.66 |
| CHEMBL341577 | — | — | 1 | 8.66 |
| CHEMBL1791000 | — | — | 1 | 8.66 |
| CHEMBL1790995 | — | — | 1 | 8.66 |
| CHEMBL334443 | — | — | 1 | 8.51 |
| CHEMBL1790997 | — | — | 1 | 8.48 |
| CHEMBL1791001 | — | — | 1 | 8.48 |
| CHEMBL1791004 | — | — | 1 | 8.41 |
| CHEMBL132595 | — | — | 1 | 8.37 |
| CHEMBL1790994 | — | — | 1 | 8.35 |
| CHEMBL334405 | — | — | 1 | 8.35 |
| CHEMBL342189 | — | — | 1 | 8.28 |
| CHEMBL1790990 | — | — | 1 | 8.21 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 8.18 |
| CHEMBL1790998 | — | — | 1 | 8.15 |
| CHEMBL1790992 | — | — | 1 | 7.52 |
| CHEMBL132652 | — | — | 1 | 7.50 |
| CHEMBL374508 | E-64 | — | 1 | 7.33 |
| CHEMBL135471 | — | — | 1 | 7.02 |
| CHEMBL134565 | — | — | 1 | 6.96 |
| CHEMBL336748 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341197 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL134494 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL336591 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL136252 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL336415 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1790993 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1790991 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1790989 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1790996 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1790999 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL341577 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1791000 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1790995 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL334443 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1791001 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1790997 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1791004 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL132595 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1790994 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL334405 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL342189 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1790990 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1790998 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1790992 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL132652 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL374508 | E-64 | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL135471 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL134565 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL336748 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL335942 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL335007 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL136024 | — | IC50 | > | 1000.0 | nM | - |