Assay Detail
Binding
CHEMBL660648
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Ability to block cathepsin L-catalyzed hydrolysis of the fluorogenic substrate Z-Phe-Arg-NHMec
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L--comparisons of potency and selectivity profiles with cathepsin B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.43 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48837 | — | — | 1 | 9.22 |
| CHEMBL51128 | — | — | 1 | 7.05 |
| CHEMBL48605 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48837 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL51128 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL48605 | — | Ki | = | 970.0 | nM | 6.01 |