Assay Detail
Binding
CHEMBL660657
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Inhibition of human Cathepsin L
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic ketone inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.63 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118449 | — | — | 1 | 7.80 |
| CHEMBL100563 | — | — | 1 | 7.41 |
| CHEMBL423995 | — | — | 1 | 7.31 |
| CHEMBL62239 | — | — | 1 | 6.60 |
| CHEMBL2371402 | — | — | 1 | 6.40 |
| CHEMBL301683 | — | — | 1 | 6.29 |
| CHEMBL349445 | — | — | 1 | 6.24 |
| CHEMBL162631 | — | — | 1 | 6.07 |
| CHEMBL61805 | — | — | 1 | 5.58 |
| CHEMBL162389 | — | — | 1 | - |
| CHEMBL436437 | — | — | 1 | - |
| CHEMBL349823 | — | — | 1 | - |
| CHEMBL161964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118449 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL100563 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL423995 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL62239 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2371402 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL301683 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL349445 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL162631 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL61805 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL162389 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL436437 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL349823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL161964 | — | Ki | > | 1000.0 | nM | - |