Assay Detail
Binding
CHEMBL660703
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Inhibition of Cyclin-dependent kinase 2 cyclin A
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.65 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276446 | — | — | 1 | 8.00 |
| CHEMBL1794057 | GW284408X | — | 1 | 5.60 |
| CHEMBL1794056 | GW301789X | — | 1 | 5.14 |
| CHEMBL175321 | — | — | 1 | 5.10 |
| CHEMBL1794058 | GW278681X | — | 1 | 5.10 |
| CHEMBL176857 | GW442130X | — | 1 | 4.98 |
| CHEMBL176544 | — | — | 1 | - |
| CHEMBL1794059 | GW275616X | — | 1 | - |
| CHEMBL369490 | — | — | 1 | - |
| CHEMBL172179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276446 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1794057 | GW284408X | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1794056 | GW301789X | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL175321 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1794058 | GW278681X | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL176857 | GW442130X | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL176544 | — | IC50 | > | 7000.0 | nM | - |
| CHEMBL1794059 | GW275616X | IC50 | > | 10000.0 | nM | - |
| CHEMBL369490 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL172179 | — | IC50 | > | 6000.0 | nM | - |