Assay Detail
Binding
CHEMBL660704
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Inhibitory activity against Cyclin-dependent kinase 2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-dependent kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60541 | — | — | 1 | 8.40 |
| CHEMBL293068 | — | — | 1 | 8.40 |
| CHEMBL294884 | — | — | 1 | 8.05 |
| CHEMBL58224 | — | — | 1 | 8.05 |
| CHEMBL432491 | — | — | 1 | 7.92 |
| CHEMBL58483 | — | — | 1 | 7.52 |
| CHEMBL57256 | — | — | 1 | 7.48 |
| CHEMBL300767 | — | — | 1 | 7.40 |
| CHEMBL58466 | — | — | 1 | 7.31 |
| CHEMBL299032 | — | — | 1 | 7.19 |
| CHEMBL58139 | — | — | 1 | 7.17 |
| CHEMBL60990 | — | — | 1 | 7.17 |
| CHEMBL59110 | — | — | 1 | 7.09 |
| CHEMBL301639 | — | — | 1 | 7.06 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 6.96 |
| CHEMBL292864 | — | — | 1 | 6.72 |
| CHEMBL417228 | — | — | 1 | 6.60 |
| CHEMBL57446 | — | — | 1 | 6.57 |
| CHEMBL293113 | — | — | 1 | 6.52 |
| CHEMBL445607 | — | — | 1 | 6.47 |
| CHEMBL57639 | — | — | 1 | 6.28 |
| CHEMBL59073 | — | — | 1 | 5.82 |
| CHEMBL57325 | — | — | 1 | 5.24 |
| CHEMBL418301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60541 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL293068 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL294884 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL58224 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL432491 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL58483 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL57256 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL300767 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL58466 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL299032 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL58139 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL60990 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL59110 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL301639 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL258805 | SU-9516 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL292864 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL417228 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL57446 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL293113 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL445607 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL57639 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL59073 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL57325 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL418301 | — | IC50 | > | 10000.0 | nM | - |