Compound Detail
CHEMBL57256
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Basic Information
| ChEMBL ID | CHEMBL57256 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HYFAEVUXFBZHKP-JYRVWZFOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
387.4
MW (Da)
1.47
ALogP
5
HBA
2
HBD
108.6
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 CHEMBL301 | IC50 | 7.48 | 7.48 | 33.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 | IC50 | = | 33.0 | nM | 7.48 | Inhibitory activity against Cyclin-dependent kinase 2 | 12749903 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12749903 | 10.1016/s0960-894x(03)00312-3 | Cyclin-dependent kinase 2 | 1 |
| 12749903 | 10.1016/s0960-894x(03)00312-3 | Vascular endothelial growth factor receptor 2 | 1 |
| 12749903 | 10.1016/s0960-894x(03)00312-3 | Platelet-derived growth factor receptor beta | 1 |
| 12749903 | 10.1016/s0960-894x(03)00312-3 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine