Assay Detail
Binding
CHEMBL660761
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Inhibitory activity against human cysteine protease, cathepsin K.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.02 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292106 | — | — | 1 | 7.96 |
| CHEMBL61051 | — | — | 1 | 7.82 |
| CHEMBL58814 | — | — | 1 | 7.72 |
| CHEMBL61826 | — | — | 1 | 7.42 |
| CHEMBL62239 | — | — | 1 | 7.36 |
| CHEMBL300347 | — | — | 1 | 7.28 |
| CHEMBL301683 | — | — | 1 | 7.22 |
| CHEMBL59115 | — | — | 1 | 7.21 |
| CHEMBL60427 | — | — | 1 | 7.19 |
| CHEMBL61805 | — | — | 1 | 6.85 |
| CHEMBL58567 | — | — | 1 | 6.75 |
| CHEMBL62014 | — | — | 1 | 6.72 |
| CHEMBL59170 | — | — | 1 | 6.38 |
| CHEMBL61482 | — | — | 1 | 6.19 |
| CHEMBL59738 | — | — | 1 | 6.15 |
| CHEMBL291628 | — | — | 1 | 6.09 |
| CHEMBL58236 | — | — | 1 | - |
| CHEMBL62042 | — | — | 1 | - |
| CHEMBL59454 | — | — | 1 | - |
| CHEMBL60898 | — | — | 1 | - |
| CHEMBL61333 | — | — | 1 | - |
| CHEMBL58166 | — | — | 1 | - |
| CHEMBL58349 | — | — | 1 | - |
| CHEMBL418645 | — | — | 1 | - |
| CHEMBL301232 | — | — | 1 | - |
| CHEMBL61730 | — | — | 1 | - |
| CHEMBL294569 | — | — | 1 | - |
| CHEMBL61758 | — | — | 1 | - |
| CHEMBL61797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292106 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL61051 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL58814 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL61826 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL62239 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL300347 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL301683 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL59115 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL60427 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL61805 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL58567 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL62014 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL59170 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL61482 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL59738 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL291628 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL58236 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL62042 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL59454 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL60898 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL61333 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL58166 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL58349 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL418645 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL301232 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL61730 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL294569 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL61758 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL61797 | — | Ki | > | 1000.0 | nM | - |