Assay Detail
Binding
CHEMBL660762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant human cathepsin K
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.76 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169448 | — | — | 1 | 8.52 |
| CHEMBL172456 | — | — | 1 | 8.52 |
| CHEMBL171403 | — | — | 1 | 8.40 |
| CHEMBL354439 | — | — | 1 | 8.30 |
| CHEMBL169560 | — | — | 1 | 8.10 |
| CHEMBL353633 | — | — | 1 | 8.05 |
| CHEMBL353725 | — | — | 1 | 8.00 |
| CHEMBL170962 | — | — | 1 | 7.92 |
| CHEMBL169708 | — | — | 1 | 7.85 |
| CHEMBL170242 | — | — | 1 | 7.82 |
| CHEMBL354132 | — | — | 1 | 7.32 |
| CHEMBL171998 | — | — | 1 | 6.15 |
| CHEMBL423447 | — | — | 1 | 5.96 |
| CHEMBL170814 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169448 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL172456 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL171403 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL354439 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL169560 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL353633 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL353725 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL170962 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL169708 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL170242 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL354132 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL171998 | — | Ki | = | 706.0 | nM | 6.15 |
| CHEMBL423447 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL170814 | — | Ki | > | 10000.0 | nM | - |