Assay Detail
Binding
CHEMBL660810
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Inhibitory activity against cyclin-dependent kinase 1-cyclin B.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.86 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434217 | — | — | 1 | 8.05 |
| CHEMBL319467 | — | — | 1 | 8.02 |
| CHEMBL122489 | — | — | 1 | 7.11 |
| CHEMBL331123 | — | — | 1 | 6.99 |
| CHEMBL436560 | — | — | 1 | 6.85 |
| CHEMBL123156 | — | — | 1 | 6.70 |
| CHEMBL123368 | — | — | 1 | 6.62 |
| CHEMBL124436 | — | — | 1 | 6.52 |
| CHEMBL332198 | — | — | 1 | 6.52 |
| CHEMBL122620 | — | — | 1 | 6.40 |
| CHEMBL122850 | — | — | 1 | 6.30 |
| CHEMBL123337 | — | — | 1 | 6.22 |
| CHEMBL123242 | — | — | 1 | 6.16 |
| CHEMBL435999 | — | — | 1 | 6.10 |
| CHEMBL125091 | — | — | 1 | 6.00 |
| CHEMBL122264 | — | — | 1 | 5.80 |
| CHEMBL122365 | — | — | 1 | 5.70 |
| CHEMBL341273 | — | — | 1 | 5.66 |
| CHEMBL122040 | — | — | 1 | 5.66 |
| CHEMBL332550 | — | — | 1 | 5.62 |
| CHEMBL338355 | — | — | 1 | 5.50 |
| CHEMBL123140 | — | — | 1 | 5.48 |
| CHEMBL124059 | — | — | 1 | 5.28 |
| CHEMBL262367 | — | — | 1 | 5.28 |
| CHEMBL122900 | — | — | 1 | 5.24 |
| CHEMBL269881 | — | — | 1 | 5.16 |
| CHEMBL332540 | — | — | 1 | 5.05 |
| CHEMBL122032 | — | — | 1 | 4.89 |
| CHEMBL330894 | — | — | 1 | 4.43 |
| CHEMBL121941 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434217 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL319467 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL122489 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL331123 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL436560 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL123156 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL123368 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL124436 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL332198 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL122620 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL122850 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL123337 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL123242 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL435999 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL125091 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL122264 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL122365 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL341273 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL122040 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL332550 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL338355 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL123140 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL124059 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL262367 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL122900 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL269881 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL332540 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL122032 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL330894 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL121941 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL121655 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL340813 | — | IC50 | = | 94000.0 | nM | 4.03 |