Assay Detail
Binding
CHEMBL660834
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Inhibitory potency of compound against human Coagulation factor Xa
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.67 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323583 | — | — | 1 | 8.30 |
| CHEMBL103342 | — | — | 1 | 8.00 |
| CHEMBL103874 | — | — | 1 | 7.96 |
| CHEMBL441463 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323583 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL103342 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL103874 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL441463 | — | Ki | = | 370.0 | nM | 6.43 |