Assay Detail
Binding
CHEMBL660932
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Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.23 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353613 | — | — | 1 | 7.00 |
| CHEMBL353422 | — | — | 1 | 6.70 |
| CHEMBL169392 | — | — | 1 | 6.52 |
| CHEMBL355558 | — | — | 1 | 6.14 |
| CHEMBL167539 | — | — | 1 | 5.85 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 5.55 |
| CHEMBL355165 | — | — | 1 | 5.37 |
| CHEMBL354754 | — | — | 1 | 5.22 |
| CHEMBL354758 | — | — | 1 | 5.10 |
| CHEMBL433726 | — | — | 1 | 5.07 |
| CHEMBL169550 | — | — | 1 | 5.05 |
| CHEMBL172564 | — | — | 1 | 4.81 |
| CHEMBL353978 | — | — | 1 | 4.55 |
| CHEMBL171999 | — | — | 1 | 4.51 |
| CHEMBL171049 | — | — | 1 | 4.48 |
| CHEMBL169303 | — | — | 1 | 4.17 |
| CHEMBL167311 | — | — | 1 | 4.12 |
| CHEMBL422212 | — | — | 1 | 4.00 |
| CHEMBL353230 | — | — | 1 | - |
| CHEMBL353694 | — | — | 1 | - |
| CHEMBL169154 | — | — | 1 | - |
| CHEMBL355288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353613 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL353422 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL169392 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL355558 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL167539 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL355165 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL354754 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL354758 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL433726 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL169550 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL172564 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL353978 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL171999 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL171049 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL169303 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL167311 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL422212 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL353230 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL353694 | — | IC50 | = | 154000.0 | nM | - |
| CHEMBL169154 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL355288 | — | IC50 | = | 280000.0 | nM | - |