Assay Detail
Binding
CHEMBL660936
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Inhibition of Class C beta-lactamase from Enterobacter cloacae strain P99
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.54 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166730 | — | — | 1 | 7.41 |
| CHEMBL353004 | — | — | 1 | 6.78 |
| CHEMBL268632 | — | — | 1 | 6.30 |
| CHEMBL171001 | — | — | 1 | 6.29 |
| CHEMBL169515 | — | — | 1 | 5.81 |
| CHEMBL169016 | — | — | 1 | 5.62 |
| CHEMBL355571 | — | — | 1 | 5.60 |
| CHEMBL435467 | — | — | 1 | 5.41 |
| CHEMBL268919 | — | — | 1 | 5.18 |
| CHEMBL355246 | — | — | 1 | 4.54 |
| CHEMBL166677 | — | — | 1 | 4.43 |
| CHEMBL355648 | — | — | 1 | 4.31 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166730 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL353004 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL268632 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL171001 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL169515 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL169016 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL355571 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL435467 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL268919 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL355246 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL166677 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL355648 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 51900.0 | nM | 4.29 |