Assay Detail
Binding
CHEMBL660938
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Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.42 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353422 | — | — | 1 | 7.70 |
| CHEMBL353613 | — | — | 1 | 7.58 |
| CHEMBL355288 | — | — | 1 | 7.54 |
| CHEMBL354754 | — | — | 1 | 7.52 |
| CHEMBL169154 | — | — | 1 | 7.00 |
| CHEMBL422212 | — | — | 1 | 7.00 |
| CHEMBL355165 | — | — | 1 | 6.75 |
| CHEMBL169392 | — | — | 1 | 6.70 |
| CHEMBL353694 | — | — | 1 | 6.54 |
| CHEMBL171999 | — | — | 1 | 6.51 |
| CHEMBL171049 | — | — | 1 | 6.40 |
| CHEMBL433726 | — | — | 1 | 6.22 |
| CHEMBL353978 | — | — | 1 | 6.16 |
| CHEMBL167539 | — | — | 1 | 6.05 |
| CHEMBL169550 | — | — | 1 | 6.05 |
| CHEMBL353230 | — | — | 1 | 5.83 |
| CHEMBL354758 | — | — | 1 | 5.64 |
| CHEMBL169303 | — | — | 1 | 5.44 |
| CHEMBL169373 | — | — | 1 | 5.18 |
| CHEMBL167311 | — | — | 1 | 4.62 |
| CHEMBL355161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353422 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL353613 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL355288 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL354754 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL169154 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL422212 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL355165 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL169392 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL353694 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL171999 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL171049 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL433726 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL353978 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL167539 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL169550 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL353230 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL354758 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL169303 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL169373 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL167311 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL355161 | — | IC50 | = | 440000.0 | nM | - |