Assay Detail
Binding
CHEMBL660939
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Inhibitory activity against Class C beta-lactamase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.09 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45136 | — | — | 1 | 8.54 |
| CHEMBL295625 | — | — | 1 | 8.52 |
| CHEMBL45084 | — | — | 1 | 8.33 |
| CHEMBL44932 | — | — | 1 | 8.26 |
| CHEMBL46478 | — | — | 1 | 7.96 |
| CHEMBL42528 | — | — | 1 | 7.66 |
| CHEMBL289979 | — | — | 1 | 7.66 |
| CHEMBL46958 | — | — | 1 | 7.50 |
| CHEMBL44278 | — | — | 1 | 7.46 |
| CHEMBL296738 | — | — | 1 | 7.42 |
| CHEMBL45273 | — | — | 1 | 7.39 |
| CHEMBL297671 | — | — | 1 | 7.23 |
| CHEMBL297805 | — | — | 1 | 7.04 |
| CHEMBL290072 | — | — | 1 | 6.96 |
| CHEMBL289526 | — | — | 1 | 6.94 |
| CHEMBL297253 | — | — | 1 | 6.90 |
| CHEMBL415918 | — | — | 1 | 6.89 |
| CHEMBL295322 | — | — | 1 | 6.76 |
| CHEMBL47198 | — | — | 1 | 6.67 |
| CHEMBL44588 | — | — | 1 | 6.51 |
| CHEMBL43955 | — | — | 1 | 6.08 |
| CHEMBL44754 | — | — | 1 | 5.96 |
| CHEMBL44813 | — | — | 1 | 5.93 |
| CHEMBL44274 | — | — | 1 | 5.38 |
| CHEMBL416447 | — | — | 1 | 5.20 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45136 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL295625 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL45084 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL44932 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL46478 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL42528 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL289979 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL46958 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL44278 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL296738 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL45273 | — | IC50 | = | 40.3 | nM | 7.39 |
| CHEMBL297671 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL297805 | — | IC50 | = | 90.7 | nM | 7.04 |
| CHEMBL290072 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL289526 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL297253 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL415918 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL295322 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL47198 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL44588 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL43955 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL44754 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL44813 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL44274 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL416447 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 101600.0 | nM | - |