Assay Detail
Binding
CHEMBL660942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GC1 extended spectrum class C beta-lactamase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae GC1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.57 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353613 | — | — | 1 | 8.00 |
| CHEMBL354754 | — | — | 1 | 7.22 |
| CHEMBL353422 | — | — | 1 | 7.00 |
| CHEMBL433726 | — | — | 1 | 7.00 |
| CHEMBL422212 | — | — | 1 | 6.89 |
| CHEMBL167539 | — | — | 1 | 6.75 |
| CHEMBL354758 | — | — | 1 | 6.58 |
| CHEMBL169392 | — | — | 1 | 6.52 |
| CHEMBL169154 | — | — | 1 | 6.05 |
| CHEMBL353978 | — | — | 1 | 5.92 |
| CHEMBL171049 | — | — | 1 | 4.35 |
| CHEMBL355161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353613 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL354754 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL353422 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL433726 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL422212 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL167539 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL354758 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL169392 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL169154 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL353978 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL171049 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL355161 | — | IC50 | = | 150000.0 | nM | - |