Assay Detail
Binding
CHEMBL660982
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DNA binding affinity (conc to decrease the fluorescence of the ethidium bromide-DNA complex by 50%)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
N-Benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.22 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448381 | — | — | 1 | 4.43 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 4.01 |
| CHEMBL543171 | — | — | 1 | - |
| CHEMBL2448379 | — | — | 1 | - |
| CHEMBL46257 | PUTRESCINE | 3.0 | 1 | - |
| CHEMBL543409 | — | — | 1 | - |
| CHEMBL540826 | — | — | 1 | - |
| CHEMBL538032 | — | — | 1 | - |
| CHEMBL543172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448381 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL19612 | SPERMIDINE | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL543171 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL2448379 | — | IC50 | = | 1382000.0 | nM | - |
| CHEMBL46257 | PUTRESCINE | IC50 | > | 11000000.0 | nM | - |
| CHEMBL543409 | — | IC50 | = | 3109000.0 | nM | - |
| CHEMBL540826 | — | IC50 | = | 341000.0 | nM | - |
| CHEMBL538032 | — | IC50 | > | 3000000.0 | nM | - |
| CHEMBL543172 | — | IC50 | = | 310000.0 | nM | - |