Compound Detail
CHEMBL2448381
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Basic Information
| ChEMBL ID | CHEMBL2448381 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LKTNSHIEOJHVRX-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3545550 |
| Active Moiety | CHEMBL3545550 |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
279.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleic Acid CHEMBL345 | IC50 | 4.43 | 4.43 | 37000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleic Acid | IC50 | = | 37000.0 | nM | 4.43 | DNA binding affinity (conc to decrease the fluorescence of the ethidium bromide-... | 11606130 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11606130 | 10.1021/jm010897q | 3LL cell line | 10 |
| 11606130 | 10.1021/jm010897q | Unchecked | 4 |
| 11606130 | 10.1021/jm010897q | U-251 | 2 |
| 11606130 | 10.1021/jm010897q | Nucleic Acid | 1 |
| 11606130 | 10.1021/jm010897q | CHO | 1 |
| 11606130 | 10.1021/jm010897q | CHO-MG | 1 |
Data from ChEMBL 36 via Core Engine