Assay Detail
Binding
CHEMBL661123
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Evaluated for inhibition of human cyclin dependent kinase 2
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
General model for estimation of the inhibition of protein kinases using Monte Carlo simulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.78 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411224 | — | — | 1 | 8.92 |
| CHEMBL270544 | GW396574X | — | 1 | 8.82 |
| CHEMBL271953 | — | — | 1 | 8.68 |
| CHEMBL269827 | GW276655X | — | 1 | 8.64 |
| CHEMBL411426 | — | — | 1 | 8.60 |
| CHEMBL271160 | — | — | 1 | 8.47 |
| CHEMBL410883 | — | — | 1 | 8.35 |
| CHEMBL314397 | — | — | 1 | 8.34 |
| CHEMBL411425 | — | — | 1 | 8.10 |
| CHEMBL272165 | GW300657X | — | 1 | 8.05 |
| CHEMBL409690 | — | — | 1 | 8.00 |
| CHEMBL273060 | — | — | 1 | 7.96 |
| CHEMBL411865 | — | — | 1 | 7.92 |
| CHEMBL260103 | — | — | 1 | 7.92 |
| CHEMBL409104 | — | — | 1 | 7.89 |
| CHEMBL411886 | — | — | 1 | 7.82 |
| CHEMBL272389 | — | — | 1 | 7.80 |
| CHEMBL409868 | — | — | 1 | 7.77 |
| CHEMBL272684 | — | — | 1 | 7.72 |
| CHEMBL271182 | — | — | 1 | 7.68 |
| CHEMBL1794054 | — | — | 1 | 7.68 |
| CHEMBL273061 | — | — | 1 | 7.47 |
| CHEMBL271183 | — | — | 1 | 7.37 |
| CHEMBL270054 | GW280670X | — | 1 | 7.37 |
| CHEMBL272387 | — | — | 1 | 7.37 |
| CHEMBL271843 | GW275944X | — | 1 | 7.34 |
| CHEMBL411491 | — | — | 1 | 7.22 |
| CHEMBL271842 | — | — | 1 | 7.13 |
| CHEMBL271594 | GW300653X | — | 1 | 7.12 |
| CHEMBL411696 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411224 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL270544 | GW396574X | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL271953 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL269827 | GW276655X | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL411426 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL271160 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL410883 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL314397 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL411425 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL272165 | GW300657X | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL409690 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273060 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL411865 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL260103 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL409104 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL411886 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL272389 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL409868 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL272684 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL271182 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1794054 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL273061 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL271183 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL270054 | GW280670X | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL272387 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL271843 | GW275944X | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL411491 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL271842 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL271594 | GW300653X | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL411696 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL438721 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL409619 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL271778 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL272885 | — | IC50 | > | 10000.0 | nM | - |