Compound Detail
CHEMBL410883
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Basic Information
| ChEMBL ID | CHEMBL410883 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSUTYZGOLFXQDG-UHFFFAOYSA-N |
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
0.20
ALogP
6
HBA
4
HBD
156.7
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK1/Cyclin A CHEMBL3038467 | IC50 | 8.55 | 8.55 | 2.8 | 1 |
| Cyclin-dependent kinase 1 CHEMBL308 | IC50 | 8.55 | 8.55 | 2.8 | 2 |
| Cyclin-dependent kinase 2 CHEMBL301 | IC50 | 8.35 | 8.35 | 4.5 | 3 |
| CDK2/Cyclin A2 CHEMBL3038469 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 1 | IC50 | = | 2.8 | nM | 8.55 | Inhibitory activity against human cyclin-dependent kinase 1 (CDK1) | 11728181 |
| Cyclin-dependent kinase 1 | IC50 | = | 2.8 | nM | 8.55 | Inhibition of CDK1 | 18271520 |
| CDK1/Cyclin A | IC50 | = | 2.8 | nM | 8.55 | Inhibition of human CDK1/cyclinA expressed in Baculovirus infected Sf9 cells usi... | 27391135 |
| Cyclin-dependent kinase 2 | IC50 | = | 4.5 | nM | 8.35 | Evaluated for inhibition of human cyclin dependent kinase 2 | 15115396 |
| Cyclin-dependent kinase 2 | IC50 | = | 4.5 | nM | 8.35 | Inhibitory activity against human cyclin-dependent kinase 2 (CDK2) | 11728181 |
| Cyclin-dependent kinase 2 | IC50 | = | 4.5 | nM | 8.35 | Inhibition of CDK2 | 18271520 |
| CDK2/Cyclin A2 | IC50 | = | 4.5 | nM | 8.35 | Inhibition of human CDK2/cyclinA expressed in Baculovirus infected T.ni cells us... | 27391135 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15115396 | 10.1021/jm0304358 | Cyclin-dependent kinase 2 | 1 |
| 11728181 | 10.1021/jm010117d | Cyclin-dependent kinase 1 | 1 |
| 11728181 | 10.1021/jm010117d | Cyclin-dependent kinase 2 | 1 |
| 18271520 | 10.1021/jm070654j | Cyclin-dependent kinase 2 | 1 |
| 18271520 | 10.1021/jm070654j | Cyclin-dependent kinase 1 | 1 |
| 27391135 | 10.1016/j.ejmech.2016.06.034 | CDK1/Cyclin A | 1 |
| 27391135 | 10.1016/j.ejmech.2016.06.034 | CDK2/Cyclin A2 | 1 |
Data from ChEMBL 36 via Core Engine