Assay Detail
Binding
CHEMBL952109
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Inhibition of CDK2
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 7.87 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411224 | — | — | 1 | 8.92 |
| CHEMBL445945 | — | — | 1 | 8.82 |
| CHEMBL270544 | GW396574X | — | 1 | 8.82 |
| CHEMBL409892 | GW305178X | — | 1 | 8.80 |
| CHEMBL271136 | — | — | 1 | 8.77 |
| CHEMBL429142 | — | — | 1 | 8.72 |
| CHEMBL411887 | — | — | 1 | 8.70 |
| CHEMBL409731 | — | — | 1 | 8.68 |
| CHEMBL271953 | — | — | 1 | 8.68 |
| CHEMBL269882 | — | — | 1 | 8.66 |
| CHEMBL269827 | GW276655X | — | 1 | 8.64 |
| CHEMBL411426 | — | — | 1 | 8.60 |
| CHEMBL270132 | — | — | 1 | 8.60 |
| CHEMBL271595 | GW297361X | — | 1 | 8.55 |
| CHEMBL269883 | GW416981X | — | 1 | 8.52 |
| CHEMBL271160 | — | — | 1 | 8.47 |
| CHEMBL410883 | — | — | 1 | 8.35 |
| CHEMBL314397 | — | — | 1 | 8.34 |
| CHEMBL272667 | — | — | 1 | 8.34 |
| CHEMBL410072 | GW301784X | — | 1 | 8.17 |
| CHEMBL407709 | — | — | 1 | 8.15 |
| CHEMBL411425 | — | — | 1 | 8.10 |
| CHEMBL408210 | — | — | 1 | 8.05 |
| CHEMBL272165 | GW300657X | — | 1 | 8.05 |
| CHEMBL272380 | — | — | 1 | 8.03 |
| CHEMBL271952 | — | — | 1 | 8.02 |
| CHEMBL409690 | — | — | 1 | 8.00 |
| CHEMBL273060 | — | — | 1 | 7.96 |
| CHEMBL272028 | GW300660X | — | 1 | 7.92 |
| CHEMBL411865 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411224 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL445945 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL270544 | GW396574X | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL409892 | GW305178X | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL271136 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL429142 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL411887 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL409731 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL271953 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL269882 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL269827 | GW276655X | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL411426 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL270132 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL271595 | GW297361X | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL269883 | GW416981X | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL271160 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL410883 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL314397 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL272667 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL410072 | GW301784X | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL407709 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL411425 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL408210 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL272165 | GW300657X | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL272380 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL271952 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL409690 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273060 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL272028 | GW300660X | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL411865 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL260103 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL272833 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL409104 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL411490 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL412091 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL411886 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL272389 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL409868 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL272684 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL272217 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL271182 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL412097 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL272026 | GW290597X | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL272668 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL273061 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL272387 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL271183 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL270054 | GW280670X | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL271843 | GW275944X | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL271137 | — | IC50 | = | 54.0 | nM | 7.27 |