Compound Detail
CHEMBL407709
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Basic Information
| ChEMBL ID | CHEMBL407709 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WZAQPWKZSBDCHK-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
373.4
MW (Da)
1.71
ALogP
7
HBA
3
HBD
126.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 CHEMBL301 | IC50 | 8.15 | 8.15 | 7.1 | 2 |
| CDK2/Cyclin A2 CHEMBL3038469 | IC50 | 8.15 | 8.15 | 7.1 | 1 |
| CDK1/Cyclin A CHEMBL3038467 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| Cyclin-dependent kinase 1 CHEMBL308 | IC50 | 7.37 | 7.37 | 43.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 | IC50 | = | 7.1 | nM | 8.15 | Inhibitory activity against human cyclin-dependent kinase 2 (CDK2) | 11728181 |
| Cyclin-dependent kinase 2 | IC50 | = | 7.1 | nM | 8.15 | Inhibition of CDK2 | 18271520 |
| CDK2/Cyclin A2 | IC50 | = | 7.1 | nM | 8.15 | Inhibition of human CDK2/cyclinA expressed in Baculovirus infected T.ni cells us... | 27391135 |
| Cyclin-dependent kinase 1 | IC50 | = | 43.0 | nM | 7.37 | Inhibitory activity against human cyclin-dependent kinase 1 (CDK1) | 11728181 |
| Cyclin-dependent kinase 1 | IC50 | = | 43.0 | nM | 7.37 | Inhibition of CDK1 | 18271520 |
| CDK1/Cyclin A | IC50 | = | 43.0 | nM | 7.37 | Inhibition of human CDK1/cyclinA expressed in Baculovirus infected Sf9 cells usi... | 27391135 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11728181 | 10.1021/jm010117d | Cyclin-dependent kinase 1 | 1 |
| 11728181 | 10.1021/jm010117d | Cyclin-dependent kinase 2 | 1 |
| 18271520 | 10.1021/jm070654j | Cyclin-dependent kinase 2 | 1 |
| 18271520 | 10.1021/jm070654j | Cyclin-dependent kinase 1 | 1 |
| 27391135 | 10.1016/j.ejmech.2016.06.034 | CDK1/Cyclin A | 1 |
| 27391135 | 10.1016/j.ejmech.2016.06.034 | CDK2/Cyclin A2 | 1 |
Data from ChEMBL 36 via Core Engine