Assay Detail
Binding
CHEMBL661126
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Inhibition of human Cyclin-dependent kinase 2 cyclin A3 at 12.5 uM ATP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.92 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303958 | — | — | 1 | 5.66 |
| CHEMBL303379 | — | — | 1 | 5.30 |
| CHEMBL68975 | — | — | 1 | 4.89 |
| CHEMBL71484 | — | — | 1 | 4.57 |
| CHEMBL431579 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303958 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL303379 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL68975 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL71484 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL431579 | — | IC50 | = | 65000.0 | nM | 4.19 |