Assay Detail
Binding
CHEMBL661268
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Compound was evaluated for inhibitory activity against Chymotrypsinogen
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.08 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170838 | — | — | 1 | 7.96 |
| CHEMBL353816 | — | — | 1 | 7.72 |
| CHEMBL352917 | — | — | 1 | 7.16 |
| CHEMBL147013 | — | — | 1 | 6.95 |
| CHEMBL170074 | — | — | 2 | 6.76 |
| CHEMBL170879 | — | — | 1 | 6.70 |
| CHEMBL171801 | — | — | 1 | 6.68 |
| CHEMBL170200 | — | — | 1 | 6.56 |
| CHEMBL172873 | — | — | 1 | 6.50 |
| CHEMBL287318 | — | — | 1 | 6.44 |
| CHEMBL170878 | — | — | 1 | 6.26 |
| CHEMBL170683 | — | — | 1 | 5.97 |
| CHEMBL369796 | — | — | 1 | 5.77 |
| CHEMBL171119 | — | — | 1 | 5.69 |
| CHEMBL170402 | — | — | 1 | 5.64 |
| CHEMBL170718 | — | — | 1 | 5.60 |
| CHEMBL171676 | — | — | 1 | 5.58 |
| CHEMBL173989 | — | — | 1 | 5.35 |
| CHEMBL171492 | — | — | 1 | 5.12 |
| CHEMBL171805 | — | — | 1 | 4.26 |
| CHEMBL171354 | — | — | 1 | 4.11 |
| CHEMBL172849 | — | — | 1 | - |
| CHEMBL355609 | — | — | 1 | - |
| CHEMBL172078 | — | — | 1 | - |
| CHEMBL368262 | — | — | 1 | - |
| CHEMBL368502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170838 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL353816 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL352917 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL147013 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL170074 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL170879 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL171801 | — | Ki | = | 207.0 | nM | 6.68 |
| CHEMBL170200 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL172873 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL287318 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL170878 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL170683 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL369796 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL171119 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL170402 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL170718 | — | Ki | = | 2510.0 | nM | 5.60 |
| CHEMBL171676 | — | Ki | = | 2620.0 | nM | 5.58 |
| CHEMBL173989 | — | Ki | = | 4430.0 | nM | 5.35 |
| CHEMBL171492 | — | Ki | = | 7550.0 | nM | 5.12 |
| CHEMBL170074 | — | Ki | = | 11900.0 | nM | 4.92 |
| CHEMBL171805 | — | Ki | = | 54900.0 | nM | 4.26 |
| CHEMBL171354 | — | Ki | = | 77400.0 | nM | 4.11 |
| CHEMBL172849 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL355609 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL172078 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL368262 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL368502 | — | Ki | > | 100000.0 | nM | - |