Assay Detail
Binding
CHEMBL661470
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Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The rational design and synthesis of non-peptide rhegnylogues of CCK-26-33 - a novel series of CCK-A selective ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.13 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.52 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 7.51 |
| CHEMBL171375 | — | — | 1 | 6.48 |
| CHEMBL169710 | — | — | 1 | 6.27 |
| CHEMBL355052 | — | — | 1 | 6.26 |
| CHEMBL170129 | — | — | 1 | 6.09 |
| CHEMBL434113 | — | — | 1 | 5.89 |
| CHEMBL319340 | — | — | 1 | 5.72 |
| CHEMBL355275 | — | — | 1 | 5.66 |
| CHEMBL9485 | — | — | 1 | 5.52 |
| CHEMBL171562 | — | — | 1 | 5.09 |
| CHEMBL352817 | — | — | 1 | 4.89 |
| CHEMBL278780 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL171375 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL169710 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL355052 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL170129 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL434113 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL319340 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL355275 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL9485 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL171562 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL352817 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL278780 | — | IC50 | = | 18000.0 | nM | 4.75 |