Assay Detail
Binding
CHEMBL661586
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Inhibition of Coagulation factor Xa
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.67 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46618 | OTAMIXABAN | 3.0 | 1 | 9.40 |
| CHEMBL296046 | — | — | 1 | 9.30 |
| CHEMBL46708 | — | — | 1 | 9.24 |
| CHEMBL295454 | — | — | 1 | 9.10 |
| CHEMBL295010 | — | — | 1 | 9.05 |
| CHEMBL44586 | — | — | 1 | 8.92 |
| CHEMBL46969 | — | — | 1 | 8.70 |
| CHEMBL47207 | — | — | 1 | 8.57 |
| CHEMBL44113 | — | — | 1 | 8.52 |
| CHEMBL45000 | — | — | 1 | 8.28 |
| CHEMBL45307 | — | — | 1 | 8.22 |
| CHEMBL415907 | — | — | 1 | 8.10 |
| CHEMBL45298 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46618 | OTAMIXABAN | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL296046 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL46708 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL295454 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL295010 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL44586 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL46969 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL47207 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL44113 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL45000 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL45307 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL415907 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL45298 | — | Ki | = | 46.0 | nM | 7.34 |