Assay Detail
Binding
CHEMBL661653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibiting CETP-mediated transfer of [3H]-CE from HDL to LDL in vitro under buffered assay conditions in human serum.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Serum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.14 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303954 | — | — | 1 | 6.22 |
| CHEMBL297971 | — | — | 1 | 5.22 |
| CHEMBL340310 | — | — | 1 | 4.70 |
| CHEMBL127895 | — | — | 1 | 4.40 |
| CHEMBL338797 | — | — | 1 | - |
| CHEMBL125473 | — | — | 1 | - |
| CHEMBL127187 | — | — | 1 | - |
| CHEMBL127319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303954 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL297971 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL340310 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL127895 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL338797 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL125473 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL127187 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL127319 | — | IC50 | = | 120000.0 | nM | - |