Assay Detail
Binding
CHEMBL661667
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Tested in vitro for inhibition of rabbit Coagulation factor X
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.67 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559015 | — | — | 1 | 9.52 |
| CHEMBL348441 | — | — | 1 | 8.59 |
| CHEMBL151939 | — | — | 1 | 8.54 |
| CHEMBL146910 | — | — | 1 | 8.37 |
| CHEMBL148944 | — | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559015 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL348441 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL151939 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL146910 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL148944 | — | Ki | = | 4.6 | nM | 8.34 |