Assay Detail
Binding
CHEMBL661696
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In vitro inhibition of cytochrome P450 19A1 in human placental microsomes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Placenta |
| Subcellular | Microsomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 9.27 | 10.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310735 | — | — | 1 | 10.43 |
| CHEMBL305205 | — | — | 1 | 10.31 |
| CHEMBL73993 | — | — | 1 | 10.30 |
| CHEMBL1629804 | — | — | 1 | 10.22 |
| CHEMBL70436 | — | — | 1 | 9.96 |
| CHEMBL307581 | — | — | 1 | 9.92 |
| CHEMBL308537 | — | — | 1 | 9.89 |
| CHEMBL72228 | — | — | 1 | 9.80 |
| CHEMBL307643 | — | — | 1 | 9.72 |
| CHEMBL304305 | — | — | 1 | 9.64 |
| CHEMBL304770 | — | — | 1 | 9.59 |
| CHEMBL307690 | — | — | 1 | 9.49 |
| CHEMBL73279 | — | — | 1 | 9.44 |
| CHEMBL70317 | — | — | 1 | 9.36 |
| CHEMBL74339 | — | — | 1 | 8.89 |
| CHEMBL73367 | — | — | 1 | 8.80 |
| CHEMBL306022 | — | — | 1 | 8.48 |
| CHEMBL70959 | — | — | 1 | 8.43 |
| CHEMBL305630 | — | — | 1 | 8.05 |
| CHEMBL72415 | — | — | 1 | 7.92 |
| CHEMBL69891 | — | — | 1 | 7.85 |
| CHEMBL73071 | — | — | 1 | 7.37 |
| CHEMBL74295 | — | — | 1 | - |
| CHEMBL72538 | — | — | 1 | - |
| CHEMBL73368 | — | — | 1 | - |
| CHEMBL72056 | — | — | 1 | - |
| CHEMBL73219 | — | — | 1 | - |
| CHEMBL307006 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310735 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL305205 | — | IC50 | = | 0.049 | nM | 10.31 |
| CHEMBL73993 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1629804 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL70436 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL307581 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL308537 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL72228 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL307643 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL304305 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL304770 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL307690 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL73279 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL70317 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL74339 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL73367 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL306022 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL70959 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL305630 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL72415 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL69891 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL73071 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL74295 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL72538 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL73368 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL72056 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL73219 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL307006 | — | IC50 | > | 50.0 | nM | - |