Assay Detail
Binding
CHEMBL661722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human testicular microsomal Cytochrome P450 17A1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.61 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310336 | — | — | 1 | 8.15 |
| CHEMBL74661 | — | — | 1 | 8.10 |
| CHEMBL78108 | — | — | 1 | 7.89 |
| CHEMBL78003 | — | — | 1 | 7.72 |
| CHEMBL307729 | — | — | 1 | 7.26 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.11 |
| CHEMBL310822 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310336 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL74661 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL78108 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL78003 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL307729 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL310822 | — | IC50 | = | 90.0 | nM | 7.05 |