Assay Detail
Binding
CHEMBL661723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human testicular microsomal Cytochrome P450 17A1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.61 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114864 | — | — | 1 | 6.82 |
| CHEMBL115944 | — | — | 1 | 6.82 |
| CHEMBL325895 | — | — | 1 | 6.82 |
| CHEMBL333604 | — | — | 1 | 6.82 |
| CHEMBL113804 | — | — | 1 | 6.82 |
| CHEMBL419743 | — | — | 1 | 6.40 |
| CHEMBL2112533 | — | — | 1 | 6.40 |
| CHEMBL419934 | — | — | 1 | 6.40 |
| CHEMBL541717 | — | — | 1 | 6.40 |
| CHEMBL113407 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114864 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL115944 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL325895 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL333604 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL113804 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL419743 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2112533 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL419934 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL541717 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL113407 | — | IC50 | = | 400.0 | nM | 6.40 |