Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL661793

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Coagulation factor X
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Isoxazolines and isoxazoles as factor Xa inhibitors.
Pruitt JR, Pinto DJ, Estrella MJ, Bostrom LL, Knabb RM, Wong PC, Wright MR, Wexler RR.
Bioorg Med Chem Lett (2000) 10 : 685 -689
PubMed 10782664 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.91 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL159816 1 10.00
CHEMBL140072 1 9.82
CHEMBL159757 1 9.30
CHEMBL351688 1 9.26
CHEMBL352099 1 9.20
CHEMBL160115 1 9.12
CHEMBL159418 1 8.80
CHEMBL436235 1 8.74
CHEMBL347838 1 8.64
CHEMBL350499 1 8.47
CHEMBL352197 1 8.47
CHEMBL351830 1 8.02
CHEMBL7967 1 7.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL159816 Ki = 0.1 nM 10.00
CHEMBL140072 Ki = 0.15 nM 9.82
CHEMBL159757 Ki = 0.5 nM 9.30
CHEMBL351688 Ki = 0.55 nM 9.26
CHEMBL352099 Ki = 0.63 nM 9.20
CHEMBL160115 Ki = 0.75 nM 9.12
CHEMBL159418 Ki = 1.6 nM 8.80
CHEMBL436235 Ki = 1.8 nM 8.74
CHEMBL347838 Ki = 2.3 nM 8.64
CHEMBL350499 Ki = 3.4 nM 8.47
CHEMBL352197 Ki = 3.4 nM 8.47
CHEMBL351830 Ki = 9.5 nM 8.02
CHEMBL7967 Ki = 11.0 nM 7.96