Assay Detail
Binding
CHEMBL661794
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Inhibitory potency was measured against human coagulation factor X
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.94 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73193 | FIDEXABAN | 2.0 | 1 | 9.96 |
| CHEMBL332322 | — | — | 1 | 9.62 |
| CHEMBL333266 | — | — | 1 | 9.59 |
| CHEMBL331690 | — | — | 1 | 9.51 |
| CHEMBL332189 | — | — | 1 | 9.48 |
| CHEMBL72318 | — | — | 1 | 9.39 |
| CHEMBL331213 | — | — | 1 | 9.37 |
| CHEMBL120438 | — | — | 1 | 9.19 |
| CHEMBL55035 | — | — | 1 | 9.18 |
| CHEMBL332388 | — | — | 1 | 9.15 |
| CHEMBL419651 | — | — | 1 | 8.92 |
| CHEMBL84065 | — | — | 1 | 8.62 |
| CHEMBL79303 | — | — | 1 | 8.41 |
| CHEMBL309541 | — | — | 1 | 8.05 |
| CHEMBL49636 | — | — | 1 | 7.89 |
| CHEMBL79986 | — | — | 1 | 7.85 |
| CHEMBL424036 | — | — | 1 | 7.62 |
| CHEMBL310373 | — | — | 1 | 7.58 |
| CHEMBL50127 | — | — | 1 | 7.28 |
| CHEMBL48604 | — | — | 1 | 7.23 |
| CHEMBL70730 | — | — | 1 | 7.10 |
| CHEMBL315014 | — | — | 1 | 7.07 |
| CHEMBL330802 | — | — | 1 | 6.89 |
| CHEMBL48864 | — | — | 1 | 6.89 |
| CHEMBL83675 | — | — | 1 | 6.80 |
| CHEMBL81579 | — | — | 1 | 6.55 |
| CHEMBL298415 | — | — | 1 | 6.40 |
| CHEMBL49786 | — | — | 1 | 6.21 |
| CHEMBL312378 | — | — | 1 | 6.19 |
| CHEMBL311608 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73193 | FIDEXABAN | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL332322 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL333266 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL331690 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL332189 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL72318 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL331213 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL120438 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL55035 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL332388 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL419651 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL84065 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL79303 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL309541 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL49636 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL79986 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL424036 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL310373 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL50127 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL48604 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL70730 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL315014 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL330802 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL48864 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL83675 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL81579 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL298415 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL49786 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL312378 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL311608 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL79735 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL81852 | — | Ki | > | 5000.0 | nM | - |