Assay Detail
Binding
CHEMBL661841
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In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and sar study of novel CCK-B antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.53 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356898 | — | — | 1 | 9.82 |
| CHEMBL2304062 | — | — | 1 | 8.77 |
| CHEMBL433384 | — | — | 1 | 8.64 |
| CHEMBL317675 | — | — | 1 | 8.03 |
| CHEMBL2304063 | — | — | 1 | 7.81 |
| CHEMBL318963 | — | — | 1 | 7.59 |
| CHEMBL2062144 | — | — | 1 | 7.47 |
| CHEMBL317577 | — | — | 1 | 7.43 |
| CHEMBL405208 | — | — | 1 | 7.39 |
| CHEMBL62205 | — | — | 1 | 7.32 |
| CHEMBL96469 | — | — | 1 | 7.19 |
| CHEMBL317626 | — | — | 1 | 7.10 |
| CHEMBL94298 | — | — | 1 | 7.04 |
| CHEMBL96401 | — | — | 1 | 6.95 |
| CHEMBL94352 | — | — | 1 | 6.75 |
| CHEMBL317062 | — | — | 1 | 6.46 |
| CHEMBL328213 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356898 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2304062 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL433384 | — | IC50 | = | 2.31 | nM | 8.64 |
| CHEMBL317675 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL2304063 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL318963 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL2062144 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL317577 | — | IC50 | = | 36.8 | nM | 7.43 |
| CHEMBL405208 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL62205 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL96469 | — | IC50 | = | 64.2 | nM | 7.19 |
| CHEMBL317626 | — | IC50 | = | 80.2 | nM | 7.10 |
| CHEMBL94298 | — | IC50 | = | 90.9 | nM | 7.04 |
| CHEMBL96401 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL94352 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL317062 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL328213 | — | IC50 | = | 532.0 | nM | 6.27 |