Assay Detail
Binding
CHEMBL661877
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Compound was tested by chromogenic assay for the inhibition of serine proteases like Human cathepsin G
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.63 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108294 | — | — | 3 | 8.08 |
| CHEMBL111705 | — | — | 1 | 7.11 |
| CHEMBL320132 | — | — | 1 | 6.70 |
| CHEMBL110995 | — | — | 1 | 5.82 |
| CHEMBL111745 | — | — | 1 | 5.18 |
| CHEMBL109601 | — | — | 1 | 4.08 |
| CHEMBL111166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108294 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL108294 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL108294 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL111705 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL320132 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL110995 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL111745 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL109601 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL111166 | — | IC50 | = | 440000.0 | nM | - |