Assay Detail
Binding
CHEMBL661887
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Inhibitory activity against human leukocyte cathepsin G (h-CG)
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.91 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108540 | — | — | 1 | 8.85 |
| CHEMBL335675 | — | — | 1 | 8.19 |
| CHEMBL134816 | — | — | 1 | 7.82 |
| CHEMBL436591 | — | — | 2 | 7.68 |
| CHEMBL424453 | — | — | 1 | 7.32 |
| CHEMBL134821 | — | — | 2 | 7.19 |
| CHEMBL134024 | — | — | 1 | 7.16 |
| CHEMBL131704 | — | — | 1 | 7.12 |
| CHEMBL135080 | — | — | 1 | 7.10 |
| CHEMBL338962 | — | — | 1 | 6.85 |
| CHEMBL134068 | — | — | 1 | 6.80 |
| CHEMBL134268 | — | — | 1 | 6.77 |
| CHEMBL336964 | — | — | 1 | 6.72 |
| CHEMBL131794 | — | — | 1 | 5.80 |
| CHEMBL134440 | — | — | 1 | 5.51 |
| CHEMBL131747 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108540 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL335675 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL134816 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL436591 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL424453 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL134821 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL134024 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL131704 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL135080 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL338962 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL134068 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL134268 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL336964 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL134821 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL436591 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL131794 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL134440 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL131747 | — | IC50 | = | 21000.0 | nM | 4.68 |