Assay Detail
Binding
CHEMBL661894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against cathepsin G
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.59 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418050 | — | — | 1 | 9.76 |
| CHEMBL285285 | — | — | 1 | 9.73 |
| CHEMBL2448441 | — | — | 1 | 9.36 |
| CHEMBL290577 | — | — | 1 | 9.04 |
| CHEMBL291026 | — | — | 1 | 8.43 |
| CHEMBL3349045 | — | — | 1 | 8.41 |
| CHEMBL288176 | — | — | 1 | 8.41 |
| CHEMBL287918 | — | — | 1 | 7.84 |
| CHEMBL36744 | — | — | 1 | 7.60 |
| CHEMBL291261 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418050 | — | Ki | = | 0.174 | nM | 9.76 |
| CHEMBL285285 | — | Ki | = | 0.187 | nM | 9.73 |
| CHEMBL2448441 | — | Ki | = | 0.437 | nM | 9.36 |
| CHEMBL290577 | — | Ki | = | 0.916 | nM | 9.04 |
| CHEMBL291026 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL3349045 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL288176 | — | Ki | = | 3.85 | nM | 8.41 |
| CHEMBL287918 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL36744 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL291261 | — | Ki | = | 44.1 | nM | 7.36 |