Assay Detail
Binding
CHEMBL661985
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Inhibition of Coagulation factor X
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 9.47 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174330 | — | — | 1 | 10.92 |
| CHEMBL171854 | — | — | 1 | 10.00 |
| CHEMBL366962 | — | — | 1 | 10.00 |
| CHEMBL176136 | — | — | 1 | 10.00 |
| CHEMBL174815 | — | — | 1 | 9.70 |
| CHEMBL366862 | — | — | 1 | 9.70 |
| CHEMBL173878 | — | — | 1 | 9.52 |
| CHEMBL174335 | — | — | 1 | 9.15 |
| CHEMBL367451 | — | — | 1 | 9.10 |
| CHEMBL444809 | — | — | 1 | 9.05 |
| CHEMBL368984 | — | — | 1 | 9.00 |
| CHEMBL369130 | — | — | 1 | 9.00 |
| CHEMBL425142 | — | — | 1 | 8.74 |
| CHEMBL368544 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174330 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL171854 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL366962 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL176136 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL174815 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL366862 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL173878 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL174335 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL367451 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL444809 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL368984 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL369130 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL425142 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL368544 | — | Ki | = | 1.8 | nM | 8.74 |