Assay Detail
Binding
CHEMBL662230
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Inhibitory activity against tissue coagulation factor VII.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.12 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78055 | — | — | 1 | 7.38 |
| CHEMBL311553 | — | — | 1 | 7.05 |
| CHEMBL275859 | — | — | 1 | 6.96 |
| CHEMBL76834 | — | — | 1 | 6.80 |
| CHEMBL337238 | — | — | 1 | 6.77 |
| CHEMBL78057 | — | — | 1 | 6.77 |
| CHEMBL339241 | — | — | 1 | 6.72 |
| CHEMBL429170 | — | — | 1 | 6.70 |
| CHEMBL78053 | — | — | 1 | 6.70 |
| CHEMBL131401 | — | — | 1 | 6.70 |
| CHEMBL77428 | — | — | 1 | 6.64 |
| CHEMBL77742 | — | — | 1 | 6.62 |
| CHEMBL1790570 | — | — | 1 | 6.52 |
| CHEMBL77142 | — | — | 1 | 6.47 |
| CHEMBL334121 | — | — | 1 | 6.30 |
| CHEMBL130464 | — | — | 1 | 6.24 |
| CHEMBL264258 | — | — | 1 | 6.17 |
| CHEMBL422973 | — | — | 1 | 6.16 |
| CHEMBL422974 | — | — | 1 | 6.16 |
| CHEMBL339341 | — | — | 1 | 6.12 |
| CHEMBL309394 | — | — | 1 | 6.10 |
| CHEMBL337930 | — | — | 1 | 6.09 |
| CHEMBL132057 | — | — | 1 | 6.05 |
| CHEMBL257867 | — | — | 1 | 5.99 |
| CHEMBL131192 | — | — | 1 | 5.89 |
| CHEMBL427751 | — | — | 1 | 5.84 |
| CHEMBL131452 | — | — | 1 | 5.82 |
| CHEMBL337014 | — | — | 1 | 5.81 |
| CHEMBL130773 | — | — | 1 | 5.74 |
| CHEMBL130592 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78055 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL311553 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL275859 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL76834 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL337238 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL78057 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL339241 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL429170 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL78053 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL131401 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL77428 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL77742 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1790570 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL77142 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL334121 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL130464 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL264258 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL422973 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL422974 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL339341 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL309394 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL337930 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL132057 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL257867 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL131192 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL427751 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL131452 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL337014 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL130773 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL130592 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL337654 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL132395 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL339956 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL130252 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL130344 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL336553 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL128019 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL407142 | — | IC50 | = | 17800.0 | nM | 4.75 |