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Target Snapshot

CHEMBL3991 Target Snapshot

Coagulation factor VII · SINGLE PROTEIN · Homo sapiens

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792Compounds
182Assays
1Approved Drugs
751.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Coagulation factor VII shows approved-linked disease relevance led by hemophilia A. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08709. Start with hemophilia A, then reuse UniProt P08709 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with hemophilia A, then reuse UniProt P08709 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
hemophilia A

Coagulation factor VII shows approved-linked disease relevance led by hemophilia A. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with hemophilia A because it currently carries approved-linked support. Linked drugs include EPTACOG ALFA (ACTIVATED), EPTACOG ALFA PEGOL (ACTIVATED), EPTACOG BETA (ACTIVATED). This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Coagulation factor VII as ChEMBL target CHEMBL3991, mapped to UniProt P08709. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Coagulation factor VII
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3991
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08709
Coagulation factor VII
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Coagulation factor VII is the right protein anchor across sources, using UniProt P08709 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why hemophilia A is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCoagulation factor VII
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP08709
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCoagulation factor VII
UniProt AccessionP08709
Component TypeProtein
Sequence Length466 aa

Coagulation factor VII

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Coagulation factor VII, mapped to UniProt P08709. Sequence length is 466 aa.

Mapped IDP08709
Review nameCoagulation factor VII
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Coagulation factor VII shows approved-linked disease relevance led by hemophilia A. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
hemophilia A
3 linked drugs · 3 direct · 3 efficacy
Linked drugEPTACOG ALFA (ACTIVATED)
Linked drugEPTACOG ALFA PEGOL (ACTIVATED)
Linked drugEPTACOG BETA (ACTIVATED)
Approved-linked Approved
hemophilia B
3 linked drugs · 3 direct · 3 efficacy
Linked drugEPTACOG ALFA (ACTIVATED)
Linked drugEPTACOG ALFA PEGOL (ACTIVATED)
Linked drugEPTACOG BETA (ACTIVATED)
Approved-linked Approved
Coagulation Protein Disorders
1 linked drug · 1 direct · 1 efficacy
Linked drugCOAGULATION FACTOR VII HUMAN
Approved-linked Approved
factor VII deficiency
1 linked drug · 1 direct · 1 efficacy
Linked drugEPTACOG ALFA (ACTIVATED)
Approved-linked Approved
Glanzmann thrombasthenia
1 linked drug · 1 direct · 1 efficacy
Linked drugEPTACOG ALFA (ACTIVATED)
Approved-linked Approved
hemophilia
1 linked drug · 1 direct · 1 efficacy
Linked drugEPTACOG ALFA (ACTIVATED)
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with hemophilia A because it currently carries approved-linked support. Linked drugs include EPTACOG ALFA (ACTIVATED), EPTACOG ALFA PEGOL (ACTIVATED), EPTACOG BETA (ACTIVATED). This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasehemophilia A
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50265.0
KI486.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3930738 10.7 Ki 0.02 Preclinical
CHEMBL3986081 10.3 Ki 0.05 Preclinical
CHEMBL3902759 9.92 Ki 0.12 Preclinical
CHEMBL3977297 9.85 Ki 0.14 Preclinical
CHEMBL3969432 9.85 Ki 0.14 Preclinical
CHEMBL3967595 9.85 Ki 0.14 Preclinical
CHEMBL3903215 9.85 Ki 0.14 Preclinical
CHEMBL3906646 9.82 Ki 0.15 Preclinical
CHEMBL3915633 9.77 Ki 0.17 Preclinical
CHEMBL3891120 9.77 Ki 0.17 Preclinical
Distribution

pChEMBL Value Distribution

49
5.0
71
5.5
90
6.0
99
6.5
72
7.0
63
7.5
30
8.0
23
8.5
19
9.0
16
9.5
pChEMBL
Assay Landscape

Assay Landscape

182
Total Assays
524
Tested Compounds
3
Assay Types
Binding — 178 assays, 524 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 173 471 6.6
cell-free format 4 42 9.3
cell-based format 1 11 6.6
Functional — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-free format 3 0 —
ADME — 1 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 14 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine