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Compound Detail

CHEMBL3969432

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COC[C@H](C)Oc1c(F)cc2cc1CN(C)C(=O)[C@H](Nc1ccc3c(N)nccc3c1)c1ccc(c(C)c1)[C@@H](C)COC(=O)N2

Basic Information

ChEMBL ID CHEMBL3969432
Phase Preclinical
Structure Type MOL
InChI Key WVVWSZKSVKZHGP-FNFPNEPISA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

615.7
MW (Da)
6.16
ALogP
8
HBA
3
HBD
128.0
PSA (Ų)
0.24
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H38FN5O5
MW 615.71
Aromatic Rings 4
Heavy Atoms 45
NP-Likeness 0.04

Activity Summary

Ki 2 meas. best 9.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor VII
CHEMBL3991
Ki 9.85 8.285 0.1 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine