Assay Detail
Functional
CHEMBL662300
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Cytotoxicity in non-NTR-expressing Chinese hamster fibroblast (V79).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | V79 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.50 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288377 | — | — | 1 | 10.10 |
| CHEMBL37705 | — | — | 1 | 9.48 |
| CHEMBL314487 | — | — | 1 | 8.59 |
| CHEMBL84381 | — | — | 1 | 7.70 |
| CHEMBL314247 | — | — | 1 | 7.51 |
| CHEMBL316382 | — | — | 1 | 7.41 |
| CHEMBL314246 | — | — | 1 | 7.38 |
| CHEMBL79354 | — | — | 1 | 7.35 |
| CHEMBL311087 | — | — | 1 | 7.32 |
| CHEMBL313563 | — | — | 1 | 7.32 |
| CHEMBL83545 | — | — | 1 | 7.27 |
| CHEMBL311195 | — | — | 1 | 7.21 |
| CHEMBL78019 | — | — | 1 | 7.20 |
| CHEMBL84463 | — | — | 1 | 7.05 |
| CHEMBL311598 | — | — | 1 | 6.80 |
| CHEMBL23612 | — | — | 1 | 4.37 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288377 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL37705 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL314487 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL84381 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL314247 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL316382 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL314246 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL79354 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL311087 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL313563 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL83545 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL311195 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL78019 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL84463 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL311598 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL23612 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 374000.0 | nM | - |