Assay Detail
Functional
CHEMBL662310
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Functional potency was determined by concentration required for activation of OX1 (Orexin-1) receptor expressed in chinese hamster ovary cells (CHO) and increasing the intracellular calcium concentration
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | ovary |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.51 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438925 | — | — | 1 | 8.68 |
| CHEMBL437062 | — | — | 1 | 6.71 |
| CHEMBL413221 | — | — | 1 | 6.46 |
| CHEMBL412459 | — | — | 1 | 6.45 |
| CHEMBL414285 | — | — | 1 | 6.19 |
| CHEMBL268561 | — | — | 1 | 6.11 |
| CHEMBL438753 | — | — | 1 | 6.08 |
| CHEMBL414043 | — | — | 1 | 6.00 |
| CHEMBL267753 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438925 | — | EC50 | = | 2.089 | nM | 8.68 |
| CHEMBL437062 | — | EC50 | = | 194.98 | nM | 6.71 |
| CHEMBL413221 | — | EC50 | = | 346.74 | nM | 6.46 |
| CHEMBL412459 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL414285 | — | EC50 | = | 645.65 | nM | 6.19 |
| CHEMBL268561 | — | EC50 | = | 776.25 | nM | 6.11 |
| CHEMBL438753 | — | EC50 | = | 831.76 | nM | 6.08 |
| CHEMBL414043 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267753 | — | EC50 | = | 1288.25 | nM | 5.89 |